GSK profiles innovative R&D portfolio to investors
03 November 2015
40 potential new medicines and vaccines offer significant opportunity to drive long-term performance and deliver new benefits to patients and consumers.
Issued: London, UK
At a presentation to investors in New York today, GSK described a deep portfolio of innovation, focussed across six core areas of scientific research and development: HIV & Infectious diseases, Oncology, Immuno-Inflammation, Vaccines, Respiratory and Rare Diseases. Around 40 new potential medicines and vaccines were profiled, supporting the Group’s outlook for growth in the period 2016-2020 and the significant opportunity the Group has to create value beyond 2020.
The portfolio represents some of the latest scientific achievements from GSK’s R&D organisation and its more than 1,500 company and academic collaborations. The company believes approximately 80% of the medicines and vaccines presented have the potential to be “first-in-class” with novel mechanisms of action. As a result, many of these potential medicines and vaccines may offer benefits beyond current standards of care and, in some cases, could radically transform how patients are treated.
In developing this portfolio, the company’s scientists have focussed on:
- Targeting immune mechanisms that could alter the fundamental course of diseases, modifying disease progression and presenting opportunities to achieve remission and functional cures.
- Developing simplified treatment regimens and a new generation of long-acting medicines to provide long-term control and improve treatment outcomes for patients.
- Using next generation technology platforms to increase understanding of fundamental disease mechanisms, to develop new approaches to disease management and control.
At the event, notable advances within the portfolio were outlined, including potential:
- Leading-edge molecules in the field of epigenetics and immuno-oncology for the treatment of cancer;
- The next generation of respiratory medicines beyond inhaled treatments;
- A portfolio of new antibodies for inflammatory diseases including rheumatoid arthritis, autoimmune diseases and osteoarthritis;
- New options for long-term control and prevention of HIV;
- Opportunities designed to cure or induce long-term remission in both Hepatitis B and C;
- Breakthrough cell and gene therapies for treatment of rare diseases;
- A novel maternal immunisation platform for vaccines.
In total GSK has the potential to file up to 20 assets with regulators before 2020. Seven of these assets are in advanced late-stage development (with the potential to launch before 2020) with the remainder, being in earlier development, notably in the areas of oncology, immuno-inflammation and respiratory disease. In 2016/2017 GSK has the potential to start phase II development of ~30 new molecular entities (NMEs) and product line extensions (PLEs) and to start phase III development of ~20 NMEs and PLEs.
During the period 2021-2025, GSK has the potential to file up to 20 additional innovative assets, now in clinical development.
Commenting on the event, Sir Andrew Witty, CEO GSK said: “Earlier this year we set out our expectations for the Group to generate sustained sales and earnings performance over the next 5 years. With the recent transaction, we have significantly strengthened our Vaccines and Consumer Healthcare businesses.
“Today, we have profiled around 40 innovative potential new medicines and vaccines which will support future growth in our Pharmaceuticals and Vaccines businesses. Several of these assets are in advanced late-stage development and, for the first time, we have also outlined the scale of new opportunities GSK has in earlier stages of development, notably in areas such as oncology and immuno-inflammation.
“The level of innovation in this portfolio is substantial. We believe this is critical in today’s operating environment as payors look to balance pressures of pricing and demand. It also provides us with confidence that this portfolio can generate significant value for shareholders and deliver widespread benefits to patients and consumers.”
GSK’s clinical research and development projects
Today the company has published on its website an updated pipeline chart, which details more than 90 clinical research projects that GSK is conducting. This, along with further details from today’s investor event, including copies of all presentations, is available at www.gsk.com.
At its Investor Day on 6 May 2015, GSK outlined a series of expectations for its performance over the five year period 2016-2020. This included an expectation that new Pharmaceutical and Vaccine products, launched in the last three years, together with contributions from current pipeline assets are expected to generate sales of at least £6 billion per annum by 2020 on a CER basis. GSK expects core EPS to grow at a CAGR of mid-to-high single digits on a CER basis over the five year period 2016-2020.
For more information see: www.gsk.com/en-gb/investors/investor-event.
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